psychoplastogen

名词 n.

英文释义

名词 n.
  1. Any of a group of small molecule drugs (notably including some psychedelics) that produce rapid and long-lasting effects on neuronal structure and function and whose use is intended to produce therapeutic benefit after a single dose.
    — Although the molecular targets of classic and dissociative psychedelics differ (5HT and NMDA receptors, respectively), their plasticity promoting properties are similar and are known to activate TrkB, mTOR, and 5HT_(2A) signaling pathways, suggesting that these key signaling hubs may serve as potential targets for the development of "psychoplastogens," fast-acting antidepressants, and anxiolytics (Ly et al., 2018).

词形变化

psychoplastogens plural

词源

Coined by American neuroscientist David E. Olson in 2018, from psycho- (“mind”) + plasto- (“plastic”) + -gen (“agent of production”), referring to the ability to rapidly promote neuronal changes via mechanisms of neuroplasticity.
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