photoxidative

— Further changes observed include RPE hypopigmentation, damage to photoreceptors including loss of outer segments, and shorter inner segments. 71 The complexities of A β -mediated activities also include the capacity to generate elevated ROS, a well-documented process in degenerative brains. 81 The retina, which is normally subject to constantly high photoxidative stresses, 82 may be particularly prone to A β -induced ROS-induced damage, in a process compounded by increasing lipofuscin accumulation within RPE cells with age.