multiple sclerotic

— In this series 21 multiple sclerotics and 23 control subjects were examined. The latter were physically healthy high-grade mental defectives, actively employed, and taken to represent ‘normal controls’.

— The suspicion that an immune reaction is involved at some stage in the pathogenesis of multiple sclerosis is implicit in much of the recent literature of the disease (Miller and Schapira, 1959). If this were so, multiple sclerotic subjects might possibly manifest an enhanced capacity to produce antibodies; or alternatively, if they are actively producing auto-antibodies, then their capacity to respond to other antigens might be diminished.