amphiphatic

— An illustrative example is the Tachyplesin family, which comprises potent antimicrobial peptides isolated from hemocytes of horseshoe crab[ 135 ] that proved useful as inhibitors of HIV replication.[ 136 ] Tachyplesins are amphiphatic peptides containing two disulfide bridges that lock the antiparallel β-hairpin conformation.[ 137 ] The presence of these disulfide bonds in natural products underlines the relevance of macrocyclization for the stabilization of isolated β-hairpin structures.